Surg&Med procedures


The Regenerative Surgery are the way to exploit and also to enhance the transplant technique of fat by enhancing the regenerative result (because of the well known stem cells contained in it ... but, mind you, without being considered a stem cell is only fat transplant even if with all its "regenerative potential", but they are different issues).
What is the difference between the "regenerative fat transplant" and the "traditional" fat grafting ?

The "traditional" fat transplant is done to restore volumes and it also deals with areas of traumatic outcomes (scarring, loss of substance): it is a "morphological" procedure because it restores the lost volumes and can be referred both to (1) cosmetic surgery for interventions in areas relevant  to it (lips, eyebrows, cheekbones, cheeks soft tissue, chin, breasts, abdomen, male and female external genitalia, buttocks and legs), and to (2) plastic surgery for interventions involving reconstruction after cancer or malformations because it is a real surgical procedure that we have been performing for years (photographic documentation is available since 2003). It is an operation which in most cases can be single (performed only once) but often, because of the need to transplant the fat in thin layers to be more easily colonized by the blood vessel (to make it more viable), the fat transplant must be repeated at a distance of at least three months and for a number of times which depends on the case.

The "regenerative" fat transplant is used (1) for anti-aging action on the skin and on distrophic (suffering) tissues of face, breasts, hands, buttocks, namely to make them "take back" and recover (also for aesthetic purposes), but is also useful (2) in cases of rehabilitation (after orthopedic intervention or maxillofacial surgery, to resume normal motility and to gain and improve the support of the adjacent tissues of the body) or even (3) in cases pertaining to the external genitalia as vulvar kraurosis (itching and dryness of vulva and vagina) or dyspareunia (pain during intercourse), or (4) for pressure ulcers. It is an outpatient practice that has only recently been codified.

Both procedures are applicable only as autologous procedures (fat must be transplanted only in the same person from whom it was taken and harvested).
In our practice we follow the guidelines (on grafting techniques for adipose tissue - lipofilling - lipostructure) of SICPRE, Italian Society of Plastic Reconstructive and Aesthetic Surgery, and of AICPE, Italian Association of Aesthetic Plastic Surgery.
The new frontier of Plastic Surgery: the "Regenerative Surgery"
The Regenerative Surgery deals with the repair, replacement and / or regeneration of cells, tissues and organs in order to restore some functions which were lost for different causes as birth defects, diseases, trauma and aging process.
But also Regenerative Medicine is playing a constant role in the field: it studies new treatment approaches that are often limited to stimulate and support the healing ability of the human body and may include the use of soluble molecules, gene therapies, therapies based on the use of stem cells and / or progenitor cells, tissue engineering and cellular reprogramming and / or tissue reprogramming.
Both of them work together only aiming to accelerate the healing process and make a three-dimensional reconstruction of damaged tissues.
An example of collaboration between Regenerative Medicine and Regenerative Surgery is the condition in which the fatty tissue surgically removed by a miniliposuction, is then treated with PRP (Platelet Rich Plasma): this amount of adipose tissue harvested and ready to be transplanted (whose regenerative capacity, through the growth factors contained in PRP, has been enhanced so achieving the goal of the stimulation of the stem cells still contained in the fat itself)  will be inserted and transplanted through microinjections in hollow areas (for example, in skin depressions of different origin, in atrophia of half the face as in Romberg syndrome, in scarring outcomes, in loss of substance after trauma, in ulcers), and also used in cosmetic surgery for minimally invasive facial rejuvenation when a face-lift is far to be required but the patient ask for a refreshing effect (through a stimulation of the native stem cells in the area), and this is true not only for the face.

Moreover, both Regenerative Medicine and Regenerative Surgery are also of  great importance and of mandatory use in the treatment of serious wounds that are struggling to heal and in the treatment of chronic ulceration.
In recent years  the steady rise in trauma from road accidents, the aging of population and the increasing related diseases, are some of the issues for the spur in the development of methods aimed at the regeneration of tissues and organs as a possible alternative to their therapy or replacement.

Therefore, only to make an example, for all those who are suffering from serious wounds that are struggling to heal, caused by traffic accidents that have caused significant loss both in hard tissues (as in the case of fractures of the facial bones and of bony structures of the various parts of the body) than in soft tissue (for example in heavy loss of substance and resulting scar), today are available these new methodologies which are expression of the highest medical research targeted to regeneration instead of replacement.
Joseph Murray, Nobel Prize 
and first surgeon to transplant a kidney
Joseph E. Murray graduated from Harvard Medical School and was interested in the transplantation of organs and tissues while working on the wounded soldiers of World War II. After the war he continued his surgical training at the Brigham and Women's Hospital, the same hospital where he died.
He became an important plastic surgeon.
In the early 50s nobody had never performed a transplant of human organs, but Murray and his collaborators (of that time named the Peter Bent Brigham Hospital in Boston)  began to develop new surgical techniques, after performing experiments with transplantation of kidneys of dogs. In December 1954, Murray and his team found the perfect patients: a 23 year old male with terminal renal failure and his identical twin (the brothers Herrick). The man who received the kidney lived for another eight years, and during that time he married a nurse known in the hospital where he had been operated and had two children.
 In the sixties,  Dr. Murray discovered the anti-rejection drugs, such as azathioprine, which enabled him to carry out transplants from donors with no family ties with the receivers. Murray then continued his research on the suppression of the immune response and won the Nobel Prize for Medicine in 1990 along with E. Donnall Thomas.
"My only wish would be to have ten more lives to pass on this planet. If it were possible I'd spend them studying embryology, genetics, physics, astronomy and geology," Murray wrote in a brief autobiography. "In one of those other lifes, I want to be a pianist, a man who lives in the woods, a tennis player and a writer for National Geographic."
Joseph Murray
Joseph E. Murray (was born in Milford on 1 April 1919 and died in Boston on Nov. 26, 2012) was the American surgeon who won, along with E. Donnall Thomas, the Nobel Prize for medicine in 1990 for "discoveries concerning transplants of cells and organs in the treatment of human diseases ".  He was the first to perform a successful kidney transplant between identical twins.
Murray, born and raised in Milford, Massachusetts, studied at the College of the Holy Cross in Worcester. Upon graduation from college, he entered at Harvard Medical School in Boston. Once graduated, he enrolled in the US Army, in whose ranks he studied surgery at Valley Forge Army Hospital in Phoenixville, Pennsylvania. It disappeared in 2012 at age 93 following a stroke, at Brigham and Women's Hospital in Boston.
Well known is the story about what a colleague of his told him when Joseph Murray was going to plan the first kidney transplant ever performed in the world. The other doctor said to him "Joe, don't get involved with this, it will ruin your career", but since the discovery of Murray and his courage in facing a challenge with the only purpose of improving patients' health, more than 600,000 people happened to have undergone an organ transplant.  Today "the world is a better place thanks to Dr. Joseph Murray". 
In December of 1954, Murray accomplished the first successful kidney transplant between identical twins (twins Herrick), at the Peter Pickle Bent Brigham Hospital. In 1959, he performed the first ALLOGENIC trasplant  and, in 1962, the first kidney transplant from a corpse. In the following years, Murray became one of the leading specialists in the fields of biology of transplants, the use of immunosuppression techniques and in the studies on the mechanisms of rejection. In the sixties, the discovery of anti-rejection drugs such as azathioprine allowed him to carry out transplants from donors with no family ties with the receivers.
Murray was chief plastic surgeon at Children's Hospital in Boston from 1972 to 1985. In addition, he was professor emeritus of surgery at Harvard Medical School.
In 1996 he was named Academic of the Pontifical Academy of Sciences at the Vatican.

Privacy Statement
Personal Privacy Statement (Article 13 Reg. EU 2016/679)
For the purposes set out in EU Regulation no. 679/2016 on the protection of natural persons with regard to the processing of personal data, we inform you that this website (  collects certain items of Personal Data from its Users. This Personal Data will be processed in compliance with the aforementioned EU Regulation, in compliance with the resulting rights and obligations.
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Place of processing: Italy, France -Privacy Policy
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Additional information on data processing
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Under 18s
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Amendments to this privacy policy
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Definitions and legal references
Personal Data (or Data)
Personal data is any information that, directly or indirectly, also in connection with any other information, including a personal identification number, makes a natural person identified or identifiable.
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The individual who uses this website and who, unless otherwise specified, is the Interested Party.
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Data Processor (or Processor)
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Data Controller (or Controller)
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This website
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The Service provided by this website as defined in the relative terms (where existing) on this website/application.
European Union (or EU)
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Small portion of data stored on the User's device.
Legal references
This privacy statement is drawn up on the basis of multiple legislative systems, including articles 13 and 14 of Regulation (EU) 2016/679.
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